The standards For Selecting Medication For any Patient
SINCE Wwii, medical science has progressed to a stage where competitive medications are for sale to treat the same ailment in numerous people. This isn’t just about brands (the industry trade issue) but generic drugs (the industry scientific issue). With this report, we shall glance at the various factors that decide your selection of a certain drug.
Safety: The subsequent sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective can be a particular drug regardless of whether they have certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but feature the opportunity side-effect of addiction.
* Long-term safety: medicine might be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and many chemicals answer produce a different chemical, that have an effect that could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other, have certain effects on a single or more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This will cause a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually produce the same influence on the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the prescription medication is more intense.
Tolerability: A medication might be effective however, not tolerable by all patients. Example: Allergies to certain drugs in some people. Short-term and long-term tolerability must be looked at. Efficacy: A medication just isn’t equally effective in all patients. By way of example, some patients with depression or anxiety attacks experience rest from escitalopram, but there are several that do not, who therefore must be prescribed another anti-depressant. The pace of start of therapeutic action is an important step to be looked at too.
Cost: Cost does not necessarily mean the expense of acquisition of a certain medicine alone. It ought to also cover the expense of management of a complication that could arise by using another drug. Example: Within a individual who insists on taking alcohol nevertheless needs to be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (including tricyclics) might cause a fresh condition in such patients, which will need a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than a cheaper tricyclic in these patients.
Simple treatment: Most effective mode of administration is preferred. If you have an alternative between an injection and oral administration, rogues is preferred when the efficacy of the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to choose simplicity of treatment.
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