Selective Androgen Receptor Modulators: Up-to-date Information and Scientific Plans

Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors based on each SARM’s chemical structure. Therefore, SARMs lead to anabolic cellular activity while avoiding many of the side effects of available given. SARMs have already been studied within the treatments for cancers of the breast and cachexia and still have been utilized as performance-enhancing agents. Here, we evaluate and summarize the existing literature on SARMs.

Aim
To provide the background, mechanisms, current and potential clinical applications, and also risks and benefits of SARMs.

Methods
A literature review was performed in MEDLINE using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancers, benign prostatic hyperplasia, libido, and muscle tissue. Both preliminary research and studies were included.

Main Outcome Measure
To complete a review of peer-reviewed literature.

Results
Although there are still no U.S. Food and Drug Agency-approved indications for SARMs, investigators are studying the potential ways to use these compounds. Preliminary research has dedicated to the pharmacokinetics and pharmacodynamics of the agents, demonstrating good availability using a paucity of drug interactions. Early studies have demonstrated potential uses for SARMs inside the management of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with good results.

Conclusion
SARMs have numerous possible clinical applications, with promise to the safe used in the treating cachexia, BPH, hypogonadism, breast cancers, and prostate cancer.

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