Selective Androgen Receptor Modulators: Recent Insight and Medical Plans

Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors according to each SARM’s chemical structure. Consequently, SARMs result in anabolic cellular activity while avoiding most of the negative effects of now available steroids. SARMs are already studied in the treatment of cancers of the breast and cachexia and possess also been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.

Aim
To provide the setting, mechanisms, current and potential clinical applications, as well as risks and advantages of SARMs.

Methods
A literature review was performed in MEDLINE while using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancers, benign prostatic hyperplasia, libido, and lean body mass. Both basic research and clinical studies were included.

Main Outcome Measure
To accomplish an assessment of peer-reviewed literature.

Results
Though there are no U.S. Drug and food Agency-approved indications for SARMs, investigators are studying the potential purposes of these compounds. Research has focused on the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability which has a paucity of drug interactions. Early clinical studies have demonstrated potential uses of SARMs inside the treatment of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancer of the breast, with good results.

Conclusion
SARMs have numerous possible clinical applications, with promise for the safe use in treating cachexia, BPH, hypogonadism, cancer of the breast, and cancer of the prostate.

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